9-Cis Retinoic Acid Protects Against Methamphetamine-Induced Neurotoxicity in Nigrostriatal Dopamine Neurons
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چکیده
منابع مشابه
Inhibition of I B Kinase- Protects Dopamine Neurons Against Lipopolysaccharide-Induced Neurotoxicity
Parkinson’s disease (PD) is a progressive neurological disorder characterized by a selective loss of dopamine (DA) neurons in the substantia nigra (SN). Although current therapy can control symptoms of this disorder, there is no effective therapy available to halt its progression. Recently, neuroinflammation has been recognized as an important contributor to the pathogenesis of PD, and nuclear ...
متن کاملResveratrol protects dopamine neurons against lipopolysaccharide-induced neurotoxicity through its anti-inflammatory actions.
Parkinson's disease (PD) is the second most common neurodegenerative disease characterized by a progressive loss of dopamine (DA) neurons in the substantia nigra. Accumulating evidence indicates that inhibition of microglia-mediated neuroinflammation may become a reliable protective strategy for PD. Resveratrol, a nonflavonoid polyphenol naturally found in red wine and grapes, has been known to...
متن کاملTitle : Resveratrol protects dopamine neurons against lipopolysaccharide - induced neurotoxicity through its anti - inflammatory actions
Neuropharmacology Section, Laboratory of Toxicology and Pharmacology (F.Z., H. Z., B. W., J. S. H., and H.-M. G.), National Institute of Environmental Health Sciences/ National Institutes of Health, Research Triangle Park, North Carolina 27709; Shanghai University of Traditional Chinese Medicine (F.Z., J.-S. S.), Shanghai 200071, China; Department of Pharmacology and Key Lab of Basic Pharmacolo...
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Methylglyoxal is a metabolite of glucose. Since serum methylglyoxal level is increased in diabetic patients, methylglyoxal is implicated in diabetic complications such as cognitive impairment. This study aimed to evaluate the effects of tenuigenin, an active component of roots of Polygala tenuifolia Willdenow, on methylglyoxal-induced cell injury in a primary culture of rat hippocampal neurons....
متن کاملCannabinoid receptor type 1 protects nigrostriatal dopaminergic neurons against MPTP neurotoxicity by inhibiting microglial activation.
This study examined whether the cannabinoid receptor type 1 (CB(1)) receptor contributes to the survival of nigrostriatal dopaminergic (DA) neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease. MPTP induced significant loss of nigrostriatal DA neurons and microglial activation in the substantia nigra (SN), visualized with tyrosine hydroxylase or ...
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ژورنال
عنوان ژورنال: Neurotoxicity Research
سال: 2013
ISSN: 1029-8428,1476-3524
DOI: 10.1007/s12640-013-9413-4